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Symmetry and scale orient min protein patterns in shaped bacterial sculptures. vcell spatial model of oscillating min proteins in bacteria sculpted into defined shapes based on experimental observations demonstrated that oscillation patterns directly capture the symmetry and scale of the cell boundary. wu, f., b.g. van schie, j.e. keymer, and c. dekker. nat nanotechnol 2015. 10:719-726. pmıd 26098227. pancreatic beta cell g-protein coupled receptors and second messenger interactions: a systems biology comp****tional analysis. vcell analysis coupling glucose metabolism, membrane potential, g-protein coupled receptors and cytosolic second messengers including calcium, camp and plc. the work demonstrates that studies of mutliple agonists and interacting pathways can help to predict pharmacological targets for modulating insulin secretion in beta cells. fridlyand, l.e., and l.h. philipson. plos one 2016. 11:e0152869. pmıd 27138453. synaptic activity regulates the abundance and binding of complexin. the flux of specific protein const**uents into and out of synaptic boutons in a living organism, caenorhabditis elegans, explored using a combination of fluorescence photoactivation imaging experiments coupled with vcell spatial modeling. wragg, r.t., g. gouzer, j. bai, g. arianna, t.a. ryan, and j.s. dittman. biophys j 2015. 108:1318-1329. pmıd 25809246. from start to fınısh: comp****tional analysis of cell cycle control in budding yeast. a new comprehensive mathematical model of cell cycle progression in yeast is reproduced in vcell. the model accounts for phenotypes of 257 mutant yeast strains and predicted 30 phenotypes of novel allele combinations. kraikivski, p., k.c. chen, t. laomettachit, t.m. murali, and j.j. tyson. npj systems biology and applications 2015. 1:15016. http://dx.doi.org/10.1038/npjsba.2015.16. dynamics of phosphoinositide-dependent signaling in sympathetic neurons. kruse, m., o. vivas, a. traynor-kaplan, and b. hille. a vcell model representing a quant**ative description of phosphoinositide metabolism in neurons. measurements coupled with modeling reveal that pıp2 synthesis is several fold faster in sympathetic neurons as compared to an electrically nonexcitable cell line. kruse, m., o. vivas, a. traynor-kaplan, and b. hille. j neurosci 2016. 36:1386-1400. pmıd 26818524. hysteresis-like binding of coagulation factors x/xa to procoagulant activated platelets and phospholipids results from multistep a***ociation and membrane-dependent multimerization. vcell models provide insight into how multi-step binding and dissociation “lock” coagulation factors on the membrane in the face of signficant flow. podoplelova, n.a., a.n. sveshnikova, j.h. kurasawa, a.g. sarafanov, h. chambost, s.a. vasil'ev, ı.a. demina, f.ı. ataullakhanov, m.c. alessi, and m.a. panteleev. 2016. biochim biophys acta 1858:1216-1227. pmıd 26874201. |